16-P010 A novel role for notch signalling in left–right determination through ciliary length control
نویسندگان
چکیده
A novel role for notch signalling in left–right determination through ciliary length control Susana Lopes, Raquel Lourenc o, Luis Pacheco, Nuno Moreno, Jill Kreiling, Leonor Saúde 1 Instituto de Medicina Molecular, Lisbon, Portugal 2 Instituto de Histologia e Biologia do Desenvolviment da Faculdade de Medicina de Lisboa, Lisbon, Portugal 3 Instituto Gulbenkian de Ciência, Oeiras, Portugal 4 Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, United States
منابع مشابه
16-P012 Gpg3, a novel ciliogenesis mutant modulating Hh signalling
A novel role for notch signalling in left–right determination through ciliary length control Susana Lopes, Raquel Lourenc o, Luis Pacheco, Nuno Moreno, Jill Kreiling, Leonor Saúde 1 Instituto de Medicina Molecular, Lisbon, Portugal 2 Instituto de Histologia e Biologia do Desenvolviment da Faculdade de Medicina de Lisboa, Lisbon, Portugal 3 Instituto Gulbenkian de Ciência, Oeiras, Portugal 4 Dep...
متن کامل16-P013 A forward genetic screen in the mouse to identify novel genes that affect motor neuron development
A novel role for notch signalling in left–right determination through ciliary length control Susana Lopes, Raquel Lourenc o, Luis Pacheco, Nuno Moreno, Jill Kreiling, Leonor Saúde 1 Instituto de Medicina Molecular, Lisbon, Portugal 2 Instituto de Histologia e Biologia do Desenvolviment da Faculdade de Medicina de Lisboa, Lisbon, Portugal 3 Instituto Gulbenkian de Ciência, Oeiras, Portugal 4 Dep...
متن کامل16-P011 Wdr35 is required for mammalian ciliogenesis and Hh responsiveness
A novel role for notch signalling in left–right determination through ciliary length control Susana Lopes, Raquel Lourenc o, Luis Pacheco, Nuno Moreno, Jill Kreiling, Leonor Saúde 1 Instituto de Medicina Molecular, Lisbon, Portugal 2 Instituto de Histologia e Biologia do Desenvolviment da Faculdade de Medicina de Lisboa, Lisbon, Portugal 3 Instituto Gulbenkian de Ciência, Oeiras, Portugal 4 Dep...
متن کاملNotch signalling regulates left-right asymmetry through ciliary length control.
The importance of cilia in embryonic development and adult physiology is emphasized by human ciliopathies. Despite its relevance, molecular signalling pathways behind cilia formation are poorly understood. We show that Notch signalling is a key pathway for cilia length control. In deltaD zebrafish mutants, cilia length is reduced in Kupffer's vesicle and can be rescued by the ciliogenic factor ...
متن کاملA conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo
Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patterning of the overlying neural tube. Increasing concentration and duration of Shh signal induces progenitors to acquire progressively more ventral fates. We show that Notch signalling augments the response of neuroepithelial cells to Shh, leading to the induction of higher expression levels of the Shh target gene Ptch1 and...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009